9 10 444 https://linen-dog.lnx.warwick.ac.uk/files/original/f06d5b0fa3fcd70758807c841885c957.pdf 4225dc642157f038c8a92790da329259 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Science, Engineering and Medicine Academic Poster An academic poster Abstract The abstract of the paper Bacteriophage are a very diverse set of bacterially targeting viral organisms with a potential to be harnessed as a replacement for antibiotics in the future. The phage Matilda is the focus of my project, and I sought to continue already concluded work on Matilda's structure, as well as produce a purer and more concentrated sample to be used under TEM. This phage has the potential to be used in the future of cystic fibrotic disease treatment, due to its affinity for the bacteria Burkholderia Cenocepacia Meta Tags Meta tags Bacteriophage, antibiotic resistance, structural biology, phage, protein mapping Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Oliver Edwards Contributor An entity responsible for making contributions to the resource Dr Jeremy Keown, Dr Jessica Lewis, Dr Antonia Sagona Subject The topic of the resource Life Sciences Title A name given to the resource Structural identification and purification of a novel bacteriophage for treatment of cystic fibrotic disease Date A point or period of time associated with an event in the lifecycle of the resource 2025 https://linen-dog.lnx.warwick.ac.uk/files/original/bb764642acc179b614770fcd3087c3cc.pdf 83548503b72e3235aab6212f6b9a971d Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Science, Engineering and Medicine Academic Paper An academic paper Abstract The abstract of the paper Within a biological system, proteins are essential; they are the building blocks of life. Their functions range from performing as antibodies to catalysing reactions as enzymes; so, proteins have an extremely varied and extensive use through a variety of industries. With mutations, their stability and functionality can be modified, with even single-point mutations having a strong effect. Therefore, being able to predict the effect in stability changes of these mutations is essential, but often computationally costly and weak when encountering unseen data. With the rise in popularity of protein language models (PLMs), including ESM, there have been improvements, but these models still encounter the same difficulties. This study explores the effect of ensemble learning on improving protein stability predictions. This is done by combining two base models: a convolutional neural network (CNN) using wild-type and mutant sequences, and a neural network trained on frozen ESM embeddings. They each form two base-learners, where each is trained on half the base training data. To combine their predictions, intermediate meta-learners for each model type and a final meta-learner are used. Results show that ensemble learning improves predictions over base models, showing improvements in all performance metrics used. Notably, even the weaker CNN-based learners contributed to improved ensemble performance, reinforcing the benefit of this type of architecture. Although it is necessary to further optimise hyperparameters and include stronger base models in the future, these results indicate that ensemble learning can lead to more accurate protein stability prediction with minimal additional computational cost. Meta Tags Meta tags protein stability predictions, mutation effect prediction, ensemble learning Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Subject The topic of the resource Computer Science Date A point or period of time associated with an event in the lifecycle of the resource 2025 Title A name given to the resource Predicting Protein Stability of Single-Point Mutations using Ensemble Learning and ESM Embeddings Creator An entity primarily responsible for making the resource Victoria Krushovska https://linen-dog.lnx.warwick.ac.uk/files/original/681107cfcd8740c8198a2fb4bfe3be8b.pdf 30f72dc92665ba68aa35e00a42d223be Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Science, Engineering and Medicine Academic Poster An academic poster Abstract The abstract of the paper The poster is about investigating the convergence of neural network in two-timescale regime. Meta Tags Meta tags Two-timescale, Neural network, Mathematics Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Yifan Wang Contributor An entity responsible for making contributions to the resource Dr. Ranko Lazic Title A name given to the resource Demonstrating the convergence of neural networks in Two-Timescale Regime Subject The topic of the resource Computer Science Date A point or period of time associated with an event in the lifecycle of the resource 2025 https://linen-dog.lnx.warwick.ac.uk/files/original/0bd2bc433e8bb4bbbc0d82eee918baca.pdf 946edee1111b9a057592187d7bc76ead Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Science, Engineering and Medicine Academic Poster An academic poster Abstract The abstract of the paper Aesthetics in video games, defined as “the desirable emotional responses evoked in the player” in the Mechanics Dynamics and Aesthetics (MDA) framework, can be key to a video game’s success. According to the MDA framework, aesthetics and user engagement are completely dependent on the mechanics of the game and cannot otherwise be influenced. However, if games are seen as an aesthetic artefact, a video game’s form and style should be entertaining on their own, and therefore its art style should influence aesthetics and user engagement. A small metroidvania-style game, Sandcat, was developed in three art styles – digital, pixel and pencil – to test this, and 15 participants played the game in all styles and completed a survey on their experiences. The results showed that while game mechanics had the most influence over aesthetics, art styles still had a significant effect on aesthetics and contributed to a game feeling more ‘usable’ for user engagement. Despite limitations with stretching and blurry assets with the pencil and pixel styles, pencil was the most preferred style (with descriptions of “whimsical” and even more “alive” than other art styles), closely followed by pixel (often described as “nostalgic”), and only one participant preferred digital. Beyond preferences, 80% of participants claimed they would spend more on a game which had their chosen art style, which may imply further commercial implications for developers. Overall, although not as strong as game mechanics, art styles still have a noteworthy influence on video game aesthetics. Meta Tags Meta tags art style, video game, aesthetic, user engagement Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Irene Peleteiro Paniagua Contributor An entity responsible for making contributions to the resource Alex Dixon Subject The topic of the resource Computer Science Title A name given to the resource Art Styles in Video Games Date A point or period of time associated with an event in the lifecycle of the resource 2025 https://linen-dog.lnx.warwick.ac.uk/files/original/b9cd734926ac2d26ce8c4594fecfb63c.pdf 052cf31fb206fac631209d2379f7ba6e Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Science, Engineering and Medicine Academic Poster An academic poster Abstract The abstract of the paper Investigating how tau protein alters synaptic plasticity in dementia sufferers Meta Tags Meta tags Dementia, tau aggregates, electrophysiology, voltage gated calcium channels Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Maahi Patel Contributor An entity responsible for making contributions to the resource Dr Emily Lane-Hill Subject The topic of the resource Dementia Title A name given to the resource How Tau Alters Synaptic Plasticity Date A point or period of time associated with an event in the lifecycle of the resource 2025 https://linen-dog.lnx.warwick.ac.uk/files/original/3977682e99d57422f25468fec5c02600.pdf df766ee911167f7272ba44c9b3088463 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Science, Engineering and Medicine Presentation Meta Tags Meta tags Protein dynamics, Computer simulations, Enzyme research, Drug discovery, Antibiotics, Protein flexibility, Molecular modelling, Catalysis, Protein design, Structural modelling, Bioinformatics, Computational chemistry, Protein function, Enzyme flexibility, Biotechnology, Synthetic biology, Protein structures, Protein–ligand interactions, Enzyme engineering, Molecular biology, Molecular Dynamics, AMBER, Protein Simulation, Computational Biochemistry, Structural Biology, NRPS, Nonribosomal Peptide Synthetase, Adenylation, Thiolation, ATP, Magnesium coordination, PPant arm, Enzyme Mechanism, Conformational Dynamics, High Performance Computing, ChimeraX, cpptraj, Parameterisation, Force Fields, Protein Engineering Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Molecular Dynamics-Driven Engineering in Non-ribosomal Peptide Synthetase 5N9X Description An account of the resource This project involved applying Molecular Dynamics (MD) simulations to study the Streptomyces adenylation–thiolation domain (PDB 5N9X) in non-ribosomal peptide synthetase (NRPS) pathways. Developed and implemented full MD workflows using the AMBER software suite on high-performance computing clusters, including parameterisation of ligands, system minimisation, equilibration, and production runs. Investigated substrate adenylation and thiolation steps, analysing conformational dynamics and catalytic geometries using Chimera and cpptraj. Creator An entity primarily responsible for making the resource Naim Ahmed Date A point or period of time associated with an event in the lifecycle of the resource 2025 Catalysis Engineering molecular Naim Ahmed peptide synthetase thiolation step https://linen-dog.lnx.warwick.ac.uk/files/original/2ace230f2fac57d7efb1852f95d0cd1f.pdf aa0728207050b25e9260e0b215161dad Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Science, Engineering and Medicine Academic Poster An academic poster Abstract The abstract of the paper Ensuring AI Safety by Understanding Behaviors and Avoiding Being Predicted by other AI Meta Tags Meta tags Game Theory, Machine Learning, Computer Science, Algorithms, Adversarial Machine Learning Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Grant Rankin Contributor An entity responsible for making contributions to the resource Grant Rankin Subject The topic of the resource Computer Science Title A name given to the resource Ensuring AI Safety by Understanding Behaviors and Avoiding Being Predicted by other AI Date A point or period of time associated with an event in the lifecycle of the resource 2025 https://linen-dog.lnx.warwick.ac.uk/files/original/45951ad8d6a4ffb56a95d8a7e07a00e4.pdf 0a9a26c45cfa275279811ed45f7a5dfc Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Science, Engineering and Medicine Academic Paper An academic paper Abstract The abstract of the paper Set theory defines much of today’s mathematics and should therefore define computer science in a similar way. Set-theoretic programming is one such way that fits computer science into a mathematical framework. This article introduces an implementation of a set-theoretical language (JMPL) as an efficient way to translate mathematical ideals to programming, while exploring relevant structure and design details. Meta Tags Meta tags #Computer Science #Set Theory #Set-theoretic Programming #Programming Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Subject The topic of the resource Set-theoretic programming Date A point or period of time associated with an event in the lifecycle of the resource 08/08/2025 Contributor An entity responsible for making contributions to the resource Joel Luckett Title A name given to the resource Implementation of a High-level Set Theoretic Programming Language https://linen-dog.lnx.warwick.ac.uk/files/original/5a5f38b81a8570657733e412d771991a.pdf 4ba1b024baf9b5a6dd3cdd9eac536495 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Science, Engineering and Medicine Academic Poster An academic poster Abstract The abstract of the paper Sleep disorders, including obstructive sleep apnoea (OSA), narcolepsy type 1 (NT1), and sleep deprivation (SD), are linked to dementia and cognitive decline. The glymphatic system, a brain clearance pathway active during slow-wave sleep, has been proposed as a mechanistic link, though its role remains debated. We conducted a systematic review and meta-analysis of preclinical and clinical studies to evaluate associations between sleep disturbances, glymphatic dysfunction, and cognition. Sleep disorders were consistently associated with impaired glymphatic clearance, with the strongest effects in OSA, supported by dose–response and cognitive analyses. These findings highlight sleep disorders as prevalent, treatable, and potentially modifiable risk factors for dementia, underscoring the public health importance of sleep in maintaining brain health. Meta Tags Meta tags sleep, glymphatic system, dementia, cognition, obstructive sleep apnoea, sleep deprivation, narcolepsy, neuroscience, meta-analysis, systematic review Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Ruth Whitehouse Contributor An entity responsible for making contributions to the resource Professor Johannes Boltze Subject The topic of the resource Systematic review and meta-analysis of glymphatic dysfunction in sleep disorders and cognitive outcomes Title A name given to the resource Systematic review and meta-analysis of glymphatic dysfunction in sleep disorders and cognitive outcomes https://linen-dog.lnx.warwick.ac.uk/files/original/4b6e1293fdb43e1a81c59c369b40da58.pdf 402234d135d48832083a4f1c220fb376 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Science, Engineering and Medicine Academic Poster An academic poster Abstract The abstract of the paper Ovarian cancer is an aggressive malignancy with limited treatment options. This study investigates the impact of the catalytic compound JPC129 on the gene expression of A2780 ovarian cancer cells via RNA sequencing. Differential expression and GO enrichment analyses identified EGR3 and IFNG as key upregulated genes, associated with hematopoiesis regulation, epithelial cell proliferation, and leukocyte cell-cell adhesion. These findings suggest that JPC129 modulates the tumor microenvironment and may influence both tumor suppression and immune dynamics, demonstrating its potential as a therapeutic candidate. Meta Tags Meta tags Science, Medicine, Bioinformatics, Ovarian Cancer Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Creator An entity primarily responsible for making the resource Susan Ahmad Dominguez Contributor An entity responsible for making contributions to the resource Dr Hannah Bridgewater Subject The topic of the resource Life Science Title A name given to the resource RNA Sequence analysis of Ovarian Cancer cells treated with novel catalytic drug