Who Wants a Coup? Quasi-experimental evidence from Sub-Saharan Africa
Military coups were a regular occurrence in West African countries in the decades that followed independence and there is growing concern they are becoming more frequent. Securing sufficient public support has often been described as key to the success of a military takeover.
Covid-19 and Intergenerational Income Mobility in the UK
Optimal Solutions of Chronotherapy Models
National Trauma in Cinematic Landscape: 3/11 Japanese Cinema as Example
National Trauma in Cinematic Landscape:3/11 Japanese Cinema as Example
Predictors of Post-traumatic Stress Among Individuals Who Survived the February 2023 Earthquakes in Turkey
Refining novel genetic biosensors for neuroactive chemicals based on in vivo detection of hydrogen peroxide.
My supervisor’s research team is investigating how neurons and glial cells communicate with each other, and to detect the release of L-Aspartate from neurons, they are expressing L-aspartate oxidase (LAOx) on the surface of mouse brain cells which generates hydrogen peroxide (H2O2) as one of the products. However, this production of H2O2 would not normally occur in brain, and therefore, it could have undesirable physiological effects. Catalase is an enzyme which metabolizes H2O2 and it could be combined in a construct with LAOx to prevent excessive accumulation of H2O2 in tissue. Microbial catalases with a high catalytic activity and a small mass would be appropriate. Such catalases could be expressed in ordered arrangements with LAOx and fluorescent proteins on mouse brain cell membranes to reduce the diffusion of H2O2 away from the detecting cells. My project therefore devised a range of constructs that combine catalase and LAOx tagged with a red fluorescent protein (mCherry) in different sequential orders to optimize oxidase-based biosensors for use in brain without overly reducing their sensitivity.
A Dialectic of Heaven and Man: A Conversation between Yijing and Hegel